This short, 2 minute interview with Professor Derek Richard will explore Vitamin B3 and explain the difference between niacinamide, nicotinamide, nicotinamide riboside and nicotinamide mononucleotide.
"Ingredient Spotlight: Vitamin B3 (Niacinamide)". Professor Derek Richard. Translational Research Institute Australia. QLD. July 2020. Transcript.
"Niacinamide is a really important component of the DNA repair that our cells and our skin have to do every day. It's broken down to a compound called NAD+, and NAD+ drops as we get older, the levels and each one of our cells falls. It's one of the key markers of ageing, or associated with ageing and what we're just doing there, is just restoring that level of NAD+ back to the normal levels.
Now, you might hear of all different chemicals with similar sounding names, they all just feed into different parts of that pathway, they all have different functions, some are more stable than others and some are brought into cells by different means than others. But they all ultimately are designed to have the same impact on the cell, and that's to produce more NAD+."
Q: Are nicotinamide and niacinamide the same thing?
A: "They are similar chemicals. They're all based off of the same chemical structure but they are slightly different. They both have similar impacts within the cell. But they are slightly different."
Q: What is the difference between nicotinamide riboside, nicotinamide and nicotinamide mononucleotide?
A: "They all ultimately have the same impact, or roughly the same impact. They do have slightly different, what we call, physiological effects. If we put nicotinamide on its own, in our cells, it's a little bit of an overload. It's a very short-lived chemical, so it'll be giving you a quick burst, and then I'll disappear after a period of time.
Nicotinamide riboside and nicotinamide mononucleotide are much longer lived compounds and they're taken into cells and then converted to NAD+, so you get a lot longer protection over that period, you get a more even protection over that period don't get this massive burst necessarily.
What we've done in the serum is really to do a combination, so put a little bit of nicotinamide in there so that we get an initial response while the nicotinamide riboside or mononucleotide that's in there can convert the nicotinamide within the cells"